Treatments
Insulin Therapy
Also Known As Insulin Replacement Therapy
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Insulin therapy treats diabetes mellitus by replacing the hormone insulin, which the body can no longer produce or use effectively. A team at the University of Toronto, physiologist John Macleod, surgeon Frederick Banting, medical student Charles Best and biochemist James Collip, isolated and purified insulin from animal pancreases over the course of 1921 and early 1922. Banting and Macleod alone received the 1923 Nobel Prize; Banting judged the choice of Macleod over Best unjust and split his own prize money with Best, and Macleod in turn split his with Collip, an implicit acknowledgment by both laureates that the official credit was too narrow. This atlas describes the history of the treatment and is not medical advice.
Facts
Disputed
Origin YearInsulin was isolated in 1921, but Best and Collip's biochemical extraction method, developed within days of each other in early 1922, was what made a purified, clinically usable insulin possible; historians still debate how credit for the discovery should be divided among the four researchers, and 1922 is used by some accounts as the true origin year of insulin as a usable treatment. Cross-Tradition Connections
Associated With
Discovered By
Worked alongside Banting through 1921 to isolate and test the extract; excluded from the 1923 Nobel Prize, which Banting split with him in protest.
Led the University of Toronto team; shared the 1923 Nobel Prize with Macleod.
Treats
Insulin therapy manages blood glucose levels; it is not a cure. Frederick Banting and Charles Best's 1921 to 1922 isolation of insulin at the University of Toronto is the founding discovery this treatment rests on.
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